Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms.

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Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms.

We have studied the effects of extracellular nucleotides on the cytosolic free calcium concentration [( Ca2+]i) in J774 macrophages using quin2 and indo-1 as indicator dyes. Micromolar quantities of ATP induced a biphasic increase in [Ca2+]i: a rapid and transient increase (peak I) which was due to mobilization of Ca2+ from intracellular stores and a second more sustained elevation (peak II) du...

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P2Z purinoceptor-associated pores induced by extracellular ATP in macrophages and J774 cells.

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1988

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(19)81521-1